Decreased mortality risk due to first acute coronary syndrome in women with postmenopausal hormone therapy use

A point I have stressed over the years is that hormone treatment in the menopause is good for your heart. It will reduce the risk of a heart attack. So when we consider that heart disease kill most women over 50 (far more than die from breast cancer), it is a very important finding. I have published many other studies over the years showing the protective effect of oestrogen on women’s cardiovascular system in the menopause.

Decreased mortality risk due to first acute coronary syndrome in women with postmenopausal hormone therapy use – <!– [if IE 6]> /wro/ayds~ie6.js<![endif]–>

Objectives

The role of postmenopausal hormone therapy (HT) in the incidence of acute coronary syndrome (ACS) has been studied extensively, but less is known of the impact of HT on the mortality risk due to an ACS.

 

Study design and main outcome measures

We extracted from a population-based ACS register, FINAMI, 7258 postmenopausal women with the first ACS. These data were combined with HT use data from the National Drug Reimbursement Register; 625 patients (9%) had used various HT regimens. The death risks due to ACS before admission to hospital, 2–28, or 29–365 days after the incident ACS were compared between HT users and non-users with logistic regression analyses.

Results

In all follow-up time points, the ACS death risks in HT ever-users were smaller compared to non-users. Of women with HT ever use, 42% died within one year as compared with 52% of non-users (OR 0.62, p < 0.001). Most deaths (84%) occurred within 28 days after the ACS, and in this group 36% of women with ever use of HT (OR 0.73, p = 0.002) and 30% of women with ≥5 year HT use (OR 0.54, p < 0.001) died as compared to 43% of the non-users. Age ≤60 or >60 years at the HT initiation was accompanied with similar reductions in ACS mortality risk.

Conclusions

Postmenopausal HT use is accompanied with reduced mortality risk after primary ACS.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on May 8, 2019, in Uncategorized. Bookmark the permalink. Leave a comment.

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