Low Dose Naltrexone in the Treatment of Fibromyalgia.

Curr Rheumatol Rev. 2018;14(2):177-180. doi: 10.2174/1573397113666170321120329.

I have been using LDN for many years for the treatment of all forms of autoimmune diseases. It generally works well in fibromyalgia as well, especially as there appears to be no other effective treatment available.

Low Dose Naltrexone in the Treatment of Fibromyalgia.

Metyas S1, Chen CL1, Yeter K1, Solyman J2, Arkfeld DG1.

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ConclusionFibromyalgia is a chronic pain disorder characterized by diffuse musculoskeletal pain, fatigue, sleep disturbance and cognitive impairment.


A significant number of fibromyalgia patients do not respond adequately to the current drugs approved by the Food and Drug Administration (FDA) for fibromyalgia treatment including pregabalin, milnacipran, duloxetine. Thus, there is still a need for adjunctive therapies.


Naltrexone is an opioid receptor antagonist used to treat alcohol and opioid dependence. It is hypothesized that low dose naltrexone causes transient blockade of opioid receptors centrally resulting in a rebound of endorphin function which may attenuate pain in fibromyalgia.


Two small prospective pilot studies have previously shown that treatment with low dose naltrexone may be an effective, safe, and inexpensive treatment for fibromyalgia.


This prospective study lends further support to the preliminary body of evidence that naltrexone is a well tolerated and likely effective treatment option in the community setting. Further large prospective controlled trials are still needed.

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About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on February 21, 2019, in Uncategorized. Bookmark the permalink. Comments Off on Low Dose Naltrexone in the Treatment of Fibromyalgia..

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