Climacteric. 2018 Nov 27:1-14. doi: 10.1080/13697137.2018.1514003. [Epub ahead of print]

Impact of micronized progesterone on body weight, body mass index, and glucose metabolism: a systematic review.

Coquoz A¹, Gruetter C², Stute P¹.

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Abstract

In women, body weight increases with age. Often menopausal hormone therapy (MHT) is blamed for enhancing this effect. In recent years, the debate on bioidentical MHT including micronized progesterone (MP) has increased. Among others, the question has been raised of whether MHT containing MP has an impact on body weight and glucose metabolism. Based on a systematic literature review on the impact of MHT containing MP on body weight, body mass index (BMI), and glucose metabolism, the following conclusions can be drawn:

estrogens combined with MP (1) either do not change or reduce body weight in normal weight postmenopausal women, (2) do not change BMI in normal and overweight postmenopausal women,

(3) do not change or improve fasting serum glucose levels in (non-)diabetic postmenopausal women, (4) do not change or improve fasting serum insulin levels in (non-)diabetic postmenopausal women, and (5) do not have an impact on serum glycated hemoglobin in postmenopausal diabetic women. This beneficial effect is probably mostly due to the estrogen MHT component.

KEYWORDS:

Micronized progesterone; body mass index; body weight; glucose metabolism; hormone therapy; menopause