The history of natural progesterone, the never-ending story.

Most of my patients on Bio-identical hormones would be on the natural progesterone. Many doctors confuse, or mislead, by referring to Progestogens (synthetic) as progesterone. There is a huge difference. The medical profession do not recommend progesterone if you have had a hysterectomy. This makes no sense as progesterone has major benefits to the neurological system of women. See the articles below.
Climacteric. 2018 May 28:1-7. doi: 10.1080/13697137.2018.1462792. [Epub ahead of print]

The history of natural progesterone, the never-ending story.

Author information

a Consultant at Besins Healthcare Global , Department of R & D, Scientific & Medical Affairs , Brussels , Belgium.


The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium. Later, progesterone was confirmed to be the best and safest method of providing luteal-phase support in assisted reproductive technology. Progesterone provides adequate endometrial protection and is suggested to be the optimal progestagen in menopausal hormone therapy in terms of cardiovascular effects, venous thromboembolism, probably stroke and even breast cancer risk. Neuroprotective effects of progesterone have also been demonstrated in several of experimental models including cerebral ischemic stroke and Alzheimer’s disease. Vaginal progesterone was shown to decrease the risk of preterm birth in women with a mid-trimester sonographic short cervix and to improve perinatal outcomes in singleton and twin gestations.

Climacteric. 2018 May 23:1-6. doi: 10.1080/13697137.2018.1463982. [Epub ahead of print]

Non-clinical studies of progesterone.

Author information

a Center for Biomedical Research , Population Council , New York , NY , USA.


Progesterone is a steroid hormone that is essential for the regulation of reproductive function. Progesterone has been approved for several indications including the treatment of anovulatory menstrual cycles, assisted reproductive technology, contraception during lactation and, when combined with estrogen, for the prevention of endometrial hyperplasia in postmenopausal hormonal therapy. In addition to its role in reproduction, progesterone regulates a number of biologically distinct processes in other tissues, particularly in the nervous system. This physiological hormone is poorly absorbed when administered in a crystalline form and is not active when given orally, unless in micronized form, or from different non-oral delivery systems that allow a more constant delivery rate. A limited number of preclinical studies have been conducted to document the toxicity, carcinogenicity and overall animal safety of progesterone delivered from different formulations, and these rather old studies showed no safety concern. More recently, it has been shown in animal experiments that progesterone, its metabolite allopregnanolone and structurally related progestins have positive effects on neuroregeneration and repair of brain damage, as well as myelin repair. These recent preclinical findings have the potential to accelerate therapeutic translation for multiple unmet neurological needs.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on June 12, 2018, in Uncategorized. Bookmark the permalink. Comments Off on The history of natural progesterone, the never-ending story..

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