Role of Estrogen and Other Sex Hormones in Brain Aging.

I have been beating the drum for years now about the benefits of estrogen for women, yet I still get women who say that have been advised to stop their HRT or not to start taking them, by their doctors or friends. I get a bit hot under the collar when I hear this as I know the damage this poor advice will do to these women. Here is more positive reasons for staying on hormones long-term – note the date of this study – a few months ago.
Front Aging Neurosci. 2017 Dec 22;9:430. doi: 10.3389/fnagi.2017.00430. eCollection 2017.

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair.

Author information

Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Departamento de Histología, Embriología, Biología Celular y Genética, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Danish Center for Molecular Gerontology and Danish Aging Research Center, Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark.
Department of Physiology, Faculty of Medicine, Complutense University, Madrid, Spain.


Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain being the most important one due to its main role in the homeostasis of the organism. As our knowledge about the underlying mechanisms of brain aging increases, potential approaches to preserve brain function rise significantly. Accumulating evidence suggests that loss of genomic maintenance may contribute to aging, especially in the central nervous system (CNS) owing to its low DNA repair capacity.

Sex hormones, particularly estrogens, possess potent antioxidant properties and play important roles in maintaining normal reproductive and non-reproductive functions. They exert neuroprotective actions and their loss during aging and natural or surgical menopause is associated with mitochondrial dysfunction, neuroinflammation, synaptic decline, cognitive impairment and increased risk of age-related disorders. Moreover, loss of sex hormones has been suggested to promote an accelerated aging phenotype eventually leading to the development of brain hypometabolism, a feature often observed in menopausal women and prodromal Alzheimer’s disease (AD).

Although data on the relation between sex hormones and DNA repair mechanisms in the brain is still limited, various investigations have linked sex hormone levels with different DNA repair enzymes. Here, we review estrogen anti-aging and neuroprotective mechanisms, which are currently an area of intense study, together with the effect they may have on the DNA repair capacity in the brain.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on February 18, 2018, in Uncategorized. Bookmark the permalink. Comments Off on Role of Estrogen and Other Sex Hormones in Brain Aging..

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