Monthly Archives: January 2018

No increased death toll for long-term menopausal hormone therapy.

I have returned to work after a break of a few weeks over the Christmas holidays. I hope you all enjoyed yourselves and remained healthy and well. I am fired up and ready for the new year and hope to be of service to you and continue to provide up to date and accurate information via these blogs. The information given comes from the best sources (universities, medical schools, Researchers) and I have vetted them for accuracy and usefulness.
Climacteric. 2017 Dec;20(6):531-532. doi: 10.1080/13697137.2017.1386651. Epub 2017 Oct 23.

No increased death toll for long-term menopausal hormone therapy.

Author information

1
a Sackler School of Medicine , Tel-Aviv University , Tel-Aviv , Israel.

Abstract

It took many years since the initial publication of data from the Women’s Health Initiative (WHI) study until further analyses and additional accumulated clinical information allowed realization of the full scope of its results. At first, the focus was on morbidity, mainly the slightly higher incidence of cardiovascular events and breast cancer cases among postmenopausal hormone users. Then, the age factor became evident, and the good safety profile of hormone therapy in healthy women initiating treatment near menopause and using it for up to 10 years eased the previous concerns. Now, 15 years after the first release of the WHI data, long-term follow-up of the WHI cohort enables consideration of mortality records as well. These data were recently summarized by the WHI investigators as follows: ‘Among postmenopausal women, hormone therapy with CEE plus MPA for a median of 5.6 years or with CEE alone for a median of 7.2 years was not associated with risk of all-cause, cardiovascular, or cancer mortality during a cumulative follow-up of 18 years.’ It seems that the bitter debate on the hazards of postmenopausal hormone therapy has come to an end, since the existing database permits clear and rationalized prescribing decisions.