Menopause, estrogens and frailty.


Gynecol Endocrinol. 2013 May;29(5):418-23. doi: 10.3109/09513590.2012.754879. Epub 2013 Feb 6.

Oestrogen is a hormone that just keeps giving to peri- and menopausal women. Frailty (also known as Sarcopenia – loss of muscle tissue) is common in older women. Oestrogen can help to avoid, or reduce, the effect of this muscle wasting. I have published previously all the other benefits of oestrogen at this time, and the safety of it in menopausal women.

Menopause, estrogens and frailty.

Author information

Nordic Bioscience – Biomarkers and Research (Part of CCBR Group), Herlev, Copenhagen, Denmark.


The controversy surrounding the results from the Women’s Health Initiative (WHI) trials published a decade ago caused a significant decline in the use of menopausal hormone replacement therapy. However, these results have been vehemently contested and several lines of evidence suggest that in perimenopausal and non-obese women, estrogen therapy may indeed be of benefit. There is ample proof that menopause causes a loss of musculoskeletal tissue mass and quality, thereby causing a loss of health and quality of life. There is also solid evidence that hormone replacement therapy in itself prevents most of these effects in connective tissue in itself. Besides the independent, direct effects on the musculoskeletal tissues, estrogen deficiency also reduces the ability to adequately respond and adapt to external mechanical and metabolic stressors, e.g. exercise, which are otherwise the main stimuli that should maintain musculoskeletal integrity and metabolic function. Thus, normophysiological estrogen levels appear to exert a permissive effect on musculoskeletal adaptations to loading, thereby likely improving the outcome of rehabilitation following critical illness, musculoskeletal trauma or orthopedic surgical therapy. These effects add to the evidence supporting the use of estrogen therapy, particularly accelerated gain of functional capacity and independence

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on July 2, 2017, in Uncategorized. Bookmark the permalink. Comments Off on Menopause, estrogens and frailty..

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