Effect of testosterone therapy on the female voice.

Climacteric. 2016 Apr;19(2):198-203. doi: 10.3109/13697137.2015.1136925. Epub 2016 Feb 9.

Effect of testosterone therapy on the female voice.

Author information

  • 1a Millennium Wellness Center, Dayton and Wright State University Boonshoft School of Medicine , Department of Surgery , Dayton , Ohio , USA ;
  • 2b York Data Analysis , Seattle , WA , USA ;
  • 3c 1st Department of Ob-Gyn , Athens University Medical School, Athens, Greece and National Institutes of Health, NICHD , Bethesda , MD , USA.



This prospective study was designed to investigate the effect of testosterone, delivered by subcutaneous implants, on the female voice.


Ten women who had opted for testosterone therapy were recruited for voice analysis. Voices were recorded prior to treatment and at 3 months, 6 months, and 12 months while on testosterone therapy. Acoustic samples were collected with subjects reading a sentence, reading a paragraph, and participating in a conversation. Significant changes in the voice over time were investigated using a repeated-measures analysis of variance with the fundamental frequency (F0) as a response variable. Demographic variables associated with characteristics of the voice were assessed.


There were no significant differences in average F0 related to smoking history, menopausal status, weight, or body mass index. There was no difference in average fundamental speaking frequency (sentence, paragraph, conversation) between the pre-treatment group and any post-treatment group at 3 and 12 months. There was an increase in sentence speech F0 at 6 months. Two of three patients with lower than expected F0 at baseline improved on testosterone therapy.


Therapeutic levels of testosterone, delivered by subcutaneous implant, had no adverse affect on the female voice including lowering or deepening of the voice.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on January 26, 2017, in Uncategorized. Bookmark the permalink. 2 Comments.

  1. Rinsing your mouth after using them may work. Otherwise they can be used as a vaginal pessary, and that will work just as well.

  2. Hello Colin. Happy New Year. I’ve been using troches for nine years now and am very happy with them. But I’m getting tired of the nasty taste in my mouth and my husband tells me I have bad breath. I have addressed all other causes of this problem and so out of desperation I thought you might have some ideas. I know the troche is the best way to deliver the hormones at they don’t involve the liver, but I was wondering if you can prescribe tablets. I’d be happy to see you or have a phone consultation if you think that there might be a suitable alternative to the troches. Thanks again for a wonderful service. Kind regards, Glenda Campbell.

    Sent from my iPhone

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