Long-Term Aspirin Use and Risk of Cancer

I have been a promoter of the benefits of low dose aspirin for many years. There is a whole chapter in my book “Live Well Over 100″devoted to the benefits of aspirin.  I have posted blogs on this before(Aspirin Use for Targeted Breast Cancer – April 4 2016, Bedtime aspirin may reduce risk of morning heart attack – April 23), but here is another reminder of how effective it can be.

Long-Term Aspirin Use and Risk of Cancer

JAMA Oncol; ePub 2016 Mar 3; Cao, Nishihara, et al

March 22, 2016

A modest but significantly reduced risk for overall cancer, especially gastrointestinal tract tumors, was observed with long-term aspirin use among 88,084 women and 47,881 men who underwent follow-up in 2 large US prospective cohort studies and reported on aspirin use biennially. Researchers found:

• Compared with nonregular use, regular aspirin use was associated with a lower risk for overall cancer (RR=0.97), which was primarily owing to a lower incidence of gastrointestinal tract cancers (RR=0.85), especially colorectal cancers (RR=0.81).

• Regular aspirin use may prevent a substantial proportion of colorectal cancers and complement the benefits of screening.

• The benefit of aspirin on gastrointestinal tracts cancers appeared evident with the use of at least 0.5 to 1.5 standard aspirin tablets per week with the minimum duration of regular use associated with a lower risk being 6 years.

• Among individuals aged ≥50 years, regular aspirin use could prevent 33 colorectal cancers per 100,000 person-years.

Citation: Cao Y, Nishihara R, Wu K, et al. Population-wide impact of long-term use of aspirin and the risk for cancer. [Published online ahead of print March 3, 2016]. JAMA Oncol. doi:10.1001/jamaoncol.2015.6396.

Commentary: This study supports and extends the recent USPSTF draft statement that recommends low-dose aspirin use for the primary prevention of cardiovascular disease (CVD) and colorectal cancer in adults ages 50 to 59 years (Grade B) and 60 to 69 years (Grade C) who have a 10% or greater 10-year CVD risk and are willing to take aspirin for at least 10 years.1 This real-world study shows that in the general population, aspirin decreases the risk of colorectal cancer as well as overall cancer risk. —Neil Skolnik, MD

1. US Preventive Services Task Force. Draft recommendation statement: aspirin to prevent cardiovascular disease and cancer. www.uspreventiveservicestaskforce.org/Page/Document/draft-recommendation-statement/aspirin-to-prevent-cardiovascular-disease-and-cancer. Published September 2015. Accessed November 2, 2015.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on August 29, 2016, in Uncategorized. Bookmark the permalink. Comments Off on Long-Term Aspirin Use and Risk of Cancer.

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