THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study.
- Giovanni Corona,
- V.a. Giagulli,
- Elisa Maseroli,
- Linda Vignozzi,
- Antonio Aversa,
- Michael Zitzmann,
- Farid Saad,
- Edoardo Mannucci and
- Mario Maggi⇑
+ Author Affiliations
G Corona, Medical Department, Azienda ASL Bologna, Endocrinology Unit, Bologna, Italy
V Giagulli, Internal medicine, O.U. of metabolic diseases and Endocrinology, Conversano, 70014, Italy
E Maseroli, Dept. of Clin. Physiopathology, University of Florence, Andrology Unit, Florence, Italy
L Vignozzi, Andrology Unit, Dept. of Clin. Physiopathology, University of Florence, Florence, I-50139, Italy
A Aversa, Medical Pathophysiology, Sapienza University of Rome , Rome, 00161, Italy
M Zitzmann, Universitätsklinikum Münster, Clinical Andrology, Muenster, 48149, Germany
F Saad, Scientific Affairs Men’s Healthcare, Bayer Schering Pharma, Berlin, Germany
E Mannucci, Department of Critical Care Medicine, University of Florence and Azienda Ospedaliera Careggi, Unit of Geriatric Medicine, Florence, 50141, Italy
M Maggi, Department of Experimental and Clinical Biomedical Sciences,University of Florence, Andrology and Sexual Medicine Unit, Florence, Italy
- Correspondence: Mario Maggi, Email: firstname.lastname@example.org
Objective. The role of testosterone (T) in regulating body composition is conflicting, thus our goal is to meta-analyze the effects of T supplementation (TS) on body composition and metabolic outcomes.
Methods. All randomized controlled trials (RCTs) comparing the effect of TS on different endpoints were considered.
Results. Overall, 59 trials were included in the study enrolling 3029 and 2049 patients in TS and control groups, respectively. TS was associated with any significant modification of body weight, waist circumference and body mass index. Conversely, TS was associated with a significant reduction of fat and with an increase of lean mass as well as with a reduction of fasting glycaemia and insulin resistance. The effect on fasting glycaemia was even higher in younger individuals and in those with metabolic diseases. When only RCTs enrolling hypogonadal (total T<12 moles/L) subjects were considered, a reduction of total cholesterol as well as of triglyceride levels were also detected. Conversely, an improvement in HDL cholesterol levels as well as in both systolic and diastolic blood pressure was not observed.
Conclusions. Our data suggest that TS is able to improve body composition and glycometabolic profile particularly in younger subjects and in those with metabolic disturbances. Specifically designed studies are urgently needed to confirm this point.