Oestrogen lowered breast cancer incidence in WHI trial
Further to my blogs of the last week: what people don’t realize is that those women in the WHI study who took oestrogen only, had a lower breast cancer incidence. Oestrogen is not as bad as most women think.
JAMA Network | JAMA | Effects of Conjugated Equine Estrogens on Breast Cancer and Mammography Screening in Postmenopausal Women With Hysterectomyhttp://www.google-analytics.com/ga.jshttp://www.google-analytics.com/analytics.js//www.googletagmanager.com/gtm.js?id=GTM-WNKSNP//ajax.googleapis.com/ajax/libs/jquery/1.6.4/jquery.min.js//
In the WHI Estrogen-Alone trial, invasive breast cancer incidence did not differ significantly between women randomized to 0.625 mg/d of CEE(Oestrogen) compared with placebo over an average 7.1 years of follow-up. Preliminary results suggesting a lower breast cancer incidence in women in the CEE group were regarded as surprising in relation to prior evidence14 and warranted a more detailed analysis. In the completed trial database, the invasive breast cancer incidence did not differ significantly between the CEE group and the placebo group (HR, 0.80; 95% CI, 0.62-1.04). However, exploratory analyses suggested that CEE might decrease breast cancer incidence in certain subgroups. In contrast, the proportion of mammograms with abnormalities requiring follow-up was significantly increased in the CEE group in the first year and in each year thereafter.