Progesterone protects against Breast Cancer.
Progesterone receptor modulates ERα action in breast cancer.
Abstract
Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its behaviour. In the presence of agonist ligands, PR associates with ERα to direct ERα chromatin binding events within breast cancer cells, resulting in a unique gene expression programme that is associated with good clinical outcome. Progesterone inhibited oestrogen-mediated growth of ERα+ cell line xenografts and primary ERα+ breast tumour explants, and had increased anti-proliferative effects when coupled with an ERα antagonist. Copy number loss of PGR, the gene coding for PR, is a common feature in ERα+ breast cancers, explaining lower PR levels in a subset of cases. Our findings indicate that PR functions as a molecular rheostat to control ERα chromatin binding and transcriptional activity, which has important implications for prognosis and therapeutic interventions.
Posted on September 23, 2015, in Uncategorized. Bookmark the permalink. 2 Comments.
Even after a hysterectomy women should take progesterone. It has many benefits, especially to the nervous system, well-being, Blood pressure and preventing breast cancer. Note: it must be micronised natural progesterone. The synthetic form is not recommended after a hysterectomy – all side effects with no benefits.
If one has had a full hysterectomy they can’t have Progesterone..can they?