Estrogen and cognition, with a focus on Alzheimer’s disease.

One of the reasons to remain on HRT long-term is the benefit to memory and reducing Alzheimer’s disease risk. Alzheimer’s disease: The Cache County memory Study concluded that taking E2 use for more than 10 years reduced the risk of Alzheimer’s disease, if treatment commences at the onset of menopause. Another study found an enduring protective role of endogenous and exogenous E2 on memory in older postmenopausal women. On my web-site under”Menopause recommendations” is the recommendation from the British Menopause Association that using oestregen long term improves cognition. Here is more information of the benefits of oestrogen to the brain. However, to get the benefits the oestrogen must be started soon after menopause begins.
Semin Reprod Med. 2005 May;23(2):172-9.

Estrogen and cognition, with a focus on Alzheimer’s disease.


Cognitive aging is associated with decreases in memory, attention, and visual/motor performance and skills. Dementia consists of loss of memory and other cognitive abilities, associated with social or occupational impairment. Potential neuroprotective effects of estrogen include lowering beta-amyloid, enhancing cholinergic function, promoting synaptic plasticity and nerve process growth, reducing oxidative stress, and enhancing brain glucose transport. Observational and longitudinal studies suggest that hormone therapy may attenuate age-associated cognitive impairment or decrease Alzheimer’s disease but this has not been confirmed by randomized clinical trials. A critical window of time may exist around the menopause when hormone therapy may delay or decrease cognitive changes; however, hormone therapy initiated in the late postmenopause does not improve global cognition and may increase dementia risk.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on August 20, 2015, in Uncategorized. Bookmark the permalink. Leave a comment.

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