Oestrogen good for Multiple Sclerosis.
We know oestrogen is good for women in many ways – but we did not know it helps MS.
Symptoms of multiple sclerosis during use of combined hormonal contraception
European Journal of Obstetrics & Gynecology and Reproductive Biology, 07/16/2015
The incidence and disease course of multiple sclerosis (MS) is influenced by sex steroids, and several studies have shown less disease activity during high estrogen states. The aim of this study was to expand on the research and determine variation in symptom experience related to the estrogen/progestogen phase in women using combined hormonal contraceptives (CHC). Researchers concluded that women with MS experience more pronounced symptoms during the pill–free, low–estrogen/progestogen phase of CHC use.
- 22 women completed self–assessments about MS symptoms in relation to CHC cycle.
- They used a symptom diary based on a validated instrument for cyclical symptoms.
- Researchers compared mean symptom scores for high and low estrogen/progestogen phases.
- Four out of ten symptoms were scored significantly higher during the pill–free week than during the CHC phase (P<0.05).