Progesterone protects against Breast Cancer.

I regularly use progesterone when treating menopausal women, even those who have had a hysterectomy. There is evidence that progesterone has breast cancer protective properties. Note however that it must be the natural, or what is known as micronised progesterone. Most HRT given to women contain progestogens, which are totally different and may cause breast cancer.

Adding Progesterone To Drugs Could Help Breast Cancer Patients: Study

By @Guneet_B on July 10 2015 4:12 PM EDT
A woman undergoes a mammograms, a special type of X-ray of the breasts, which is used to detect tumours as part of a regular cancer prevention medical check-up at a clinic in Nice
Progesterone can help slow tumor cells, a recent study says. Reuters

Adding the female hormone progesterone to breast cancer drugs could help nearly 50 percent of the world’s breast cancer patients, a recent study says. The study — published in the journal Nature — claims that progesterone can help slow tumor growth in breast cancer patients.

Currently, medical staff use drugs such as Tamoxifen to block estrogen receptors in tumor cells. Such receptors are known to cause tumor growth. It was long observed that women who had progesterone receptors as well had a far better outlook. However, researchers didn’t know why.

To find out why, scientists from Cancer Research UK’s Cambridge Research Institute and Australia’s Univeristy of Adelaide studied the mechanism involved. They found that the progesterone receptors changed the behavior of the tumor cells by “talking to” the estrogen receptors. This resulted in slow growth of the breast cancer tumor cells.

“This important laboratory research helps explain why some breast cancer patients have a better outlook. Crucially, it provides a strong case for a clinical trial to investigate the potential benefit of adding progesterone to drugs that target the estrogen receptor, which could improve treatment for the majority of hormone-driven breast cancers,” said Dr. Jason Caroll of Cancer Research UK, in a news release.

The researchers believe that this method of controlling the growth of the breast cancer cells is cheap, effective and safe. In addition, the wide availability of progesterone could potentially help provide an improved and timely treatment to the breast cancer patients.

Nature. 2015 Jul 8. doi: 10.1038/nature14583. [Epub ahead of print]

Progesterone receptor modulates ERα action in breast cancer.

Abstract

Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its behaviour. In the presence of agonist ligands, PR associates with ERα to direct ERα chromatin binding events within breast cancer cells, resulting in a unique gene expression programme that is associated with good clinical outcome. Progesterone inhibited oestrogen-mediated growth of ERα+ cell line xenografts and primary ERα+ breast tumour explants, and had increased anti-proliferative effects when coupled with an ERα antagonist. Copy number loss of PGR, the gene coding for PR, is a common feature in ERα+ breast cancers, explaining lower PR levels in a subset of cases. Our findings indicate that PR functions as a molecular rheostat to control ERα chromatin binding and transcriptional activity, which has important implications for prognosis and therapeutic interventions.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on July 20, 2015, in Uncategorized. Bookmark the permalink. Leave a comment.

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