Midlife Fitness Linked to Cancer Risk and Mortality

Commentary:  The beneficial effects of exercise on cardiovascular disease prevention are well appreciated.  The beneficial effects of exercise on cancer prevention are less well known, but equally important. This study adds to the current body of literature that shows that exercise helps decrease the incidence of many types of cancers.1   The American Cancer Society has estimated that one-third of the more than 572,000 cancer deaths that occur in the United States each year can be attributed to diet and physical activity habits. Physical activity may reduce the risk of cancers of the breast, colon and endometrium, advanced prostate cancer, and possibly, pancreatic cancer.2 –Neil Skolnik, MD

Midlife Fitness Linked to Cancer Risk and Mortality

Results from the Cooper Center Longitudinal Study
April 7, 2015

Cardiorespiratory fitness (CRF) in midlife is inversely associated with incident lung and colorectal cancer, but not prostate cancer, according to a prospective observational cohort study of 13,949 men with a baseline fitness examination in the Cooper Center Longitudinal Study.

Researchers used age- and sex-specific distribution to define fitness groups as those with low (lowest 20%), moderate (middle 40%), or high (upper 40%) CRF.

Compared with the low CRF group, the adjusted hazard ratios for incident cancers among men with high CRF are as follows:

• Lung: 0.45

• Colorectal: 0.56

• Prostate: 1.22

In addition, high CRF in midlife was associated with a 32% risk reduction in cancer-related deaths among those diagnosed with cancer at Medicare age, and a 68% reduction in cardiovascular mortality following a cancer diagnosis.

Citation: Lakoski SG, Willis BL, Barlow CE, et al. Midlife cardiorespiratory fitness, incident cancer, and survival after cancer in men: The Cooper Center Longitudinal Study. JAMA Oncol. doi:10.1001/jamaoncol.2015.0226. 


1.  Spring B, Ockene JK, Gidding SS, Mozaffarian D, Moore S, Rosal MC, et al; American Heart Association Behavior Change Committee of the Council on Epidemiology and Prevention, Council on Lifestyle and Cardiometabolic Health, Council for High Blood Pressure Research, and Council on Cardiovascular and Stroke Nursing. AHA – Science Advisory: Better population health through behavior change in adults. Circulation. 2013 Nov 5;128(19):2169-2176. doi: 10.1161/01.cir.0000435173.25936.e1.

2. Kushi LH, Doyle C, McCullough M, Rock CL, Demark-Wahnefried W, Bandera EV, et al; American Cancer Society 2010 Nutrition and Physical Activity Guidelines Advisory Committee. American Cancer Society Guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2012 Jan-Feb;62(1):30-67. doi: 10.3322/caac.20140

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on June 24, 2015, in Uncategorized. Bookmark the permalink. Leave a comment.

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