Estrogens and the intervertebral disc

Estrogens and the intervertebral disc

  1. J Calleja-Agius
  2. Y Muscat-Baron
  3. M P Brincat

  1. Department of Obstetrics and Gynaecology, Mater Dei Hospital, Malta
  1. Correspondence: Dr J Calleja-Agius MRCOG MRCPI, 12 ‘Mon Nid’, Gianni Faure Street, Tarxien TXN2421, Malta. Email: jean@waldonet.net.mt

Abstract

Intervertebral discs are an integral part of the vertebral column. It has been shown that menopause has a negative effect on bone and on intervertebral discs.Estrogen has a beneficial effect of preserving the health of collagen-containing tissues, including the intervertebral disc.The intervertebral disc allows for mobility of the spine, and maintains a uniform stress distribution of the area of the vertebral endplates. Also, the disc influences spinal height. The disc tissue is adapted for this biomechanical function. The function of the spine is impaired if there is a loss of disc tissue. Narrowing of the disc space due to degeneration of intervertebral discs is associated with a significantly increased risk of vertebral fractures. Estrogen should be seen as the first-choice therapy for bones and other collagen-rich tissues, such as intervertebral discs, because it maintains homeostasis of the bone-remodelling unit. Unlike bisphosphonates, estrogen is unique in its ability to regenerate bone collagen after its disintegration, apart from suppressing osteoclastic activity. Besides, there is insufficient data on deterioration in bone qualities and micro-cracks in patients on long-term bisphosphonates

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on January 12, 2014, in Uncategorized. Bookmark the permalink. Leave a comment.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: