Estrogen: A master regulator of bioenergetic systems in the brain and body.

Front Neuroendocrinol. 2013 Aug 29. pii: S0091-3022(13)00043-5. doi: 10.1016/j.yfrne.2013.08.001. [Epub ahead of print]

Estrogen: A master regulator of bioenergetic systems in the brain and body.


Neuroscience Department, University of Southern California, Los Angeles, CA 90033, United States.


Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen protects against adiposity, insulin resistance, and type II diabetes, and regulates energy intake and expenditure. During menopause, decline in circulating estrogen is coincident with decline in brain bioenergetics and shift towards a metabolically compromised phenotype. Compensatory bioenergetic adaptations, or lack thereof, to estrogen loss could determine risk of late-onset Alzheimer’s disease. Estrogen coordinates brain and body metabolism, such that peripheral metabolic state can indicate bioenergetic status of the brain. By generating biomarker profiles that encompass peripheral metabolic changes occurring with menopause, individual risk profiles for decreased brain bioenergetics and cognitive decline can be created. Biomarker profiles could identify women at risk while also serving as indicators of efficacy of hormone therapy or other preventative interventions.

Copyright © 2013 Elsevier Inc. All rights reserved.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on January 8, 2014, in Uncategorized. Bookmark the permalink. 3 Comments.

  1. Thanks for you reply Dr Holloway. I am finding the articles in the blog very interesting and look forward to further posts.

  2. This post is heavy on scientific lingo, much of which I do not understand. However, the basic gist is that oestrogen is valuable and helpful for women’s nervous system. It was written by scientific researchers for other scientific researchers (hence the fancy words) and not for the general public. The reason I posted it was that I thought women may be interested in the latest research about oestrogen, considering the interest women have about this important female hormone.

  3. I have two questions regarding this post. What are the compensatory bio energetic adaptions that occur, and what are the ‘biomarker profiles’ that could identify women at risk? Is this a test that is available to determine predisposition to Alzheimer’s Disease?

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