What do you know – Another major study proves natural hormones better than synthetic.

Do not worry about the confusing genetic and biochemical terminology. This is all medical/expert speak. The important bit is in the conclusion, which I have highlighted. And yet, there are still some doctors who defend the synthetic HRT as being safer than the natural HRT, in spite of the overwhelming evidence.
Gynecol Endocrinol. 2012 Oct;28 Suppl 2:12-5. Epub 2012 Jul 27.

Percutaneous estradiol/oral micronized progesterone has less-adverse effects and different gene regulations than oral conjugated equine estrogens/medroxyprogesterone acetate in the breasts of healthy women in vivo.


Department of Obsterics and Gynecology, Södertälje Hospital, Södertälje, Sweden.


Gene expression analysis of healthy postmenopausal women in a prospective clinical study indicated that genes encoding for epithelial proliferation markers Ki-67 and progesterone receptor B mRNA are differentially expressed in women using hormone therapy (HT) with natural versus synthetic estrogens. Two 28-day cycles of daily estradiol (E2) gel 1.5 mg and oral micronized progesterone (P) 200 mg/day for the last 14 days of each cycle did not significantly increase breast epithelial proliferation (Ki-67 MIB-1 positive cells) at the cell level nor at the mRNA level (MKI-67 gene). A borderline significant beneficial reduction in anti-apoptotic protein bcl-2, favouring apoptosis, was also seen followed by a slight numeric decrease of its mRNA. By contrast, two 28-day cycles of daily oral conjugated equine estrogens (CEE) 0.625 mg and oral medroxyprogesterone acetate (MPA) 5 mg for the last 14 days of each cycle significantly increased proliferation at both the cell level and at the mRNA level, and significantly enhanced mammographic breast density, an important risk factor for breast cancer. In addition, CEE/MPA affected around 2,500 genes compared with just 600 affected by E2/P. These results suggest that HT with natural estrogens affects a much smaller number of genes and has less-adverse effects on the normal breast in vivo than conventional, synthetic therapy.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on September 9, 2013, in Uncategorized. Bookmark the permalink. Leave a comment.

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