Oestrogen helps Arthritis.

Oestrogen is a wonderful hormone that is often misunderstood. More and more research is showing the benefits of this hormone to women.  Gynecologist Robert Wilson coined the term “Feminine Forever” in 1960 indicating the benefits of oestrogen to menopausal women. Recent research (see under “Safety of BHRT” under heading Natural hormones on this website) shows that oestrogen does not increase the risk of breast cancer if started soon after menopause and given transdermally- through the skin such as troches and cream. Now we have research showing Oestrogens benefits to our joints as we age. If you want to know more about the benefits of oestrogen, look under the heading “More on HRT” and sub-heading “Benefits” on this website.
Menopause Int. 2012 Sep 28. [Epub ahead of print]

The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: may estrogen be a magic bullet?


Nordic Bioscience A/S, Herlev, Denmark.


The female predominance of polyarticular osteoarthritis (OA), and in particular the marked increase of OA in women after the menopause points to a likely involvement of female sex hormones in the maintenance of cartilage homeostasis. This perception has inspired many research groups to investigate the role of estrogens in the modulation of cartilage homeostasis with the ultimate aim to clarify whether estrogen replacement therapy (ERT) could provide benefits in preventing the rapid rise in the prevalence of OA in postmenopausal women. The effects of ERT and selective estrogen-receptor modulators on the joint in various experimental models have been investigated. Clinically, the effects of estrogens have been evaluated by post hoc analysis in clinical trials using biochemical markers of cartilage and bone degradation. Lastly, the Women’s Health Initiative trial (WHI) investigated the effects of estrogens on the joint and joint replacements.Even though the exact mode of action still needs to be elucidated, the effect involves both direct and indirect mechanisms on the whole joint pathophysiology. Several animal models have demonstrated structural benefits of estrogens, as well as significant effects on joint inflammation.

This is in complete alignment with clinical data using biochemical markers of joint degradation which demonstrated approximately 50% inhibition of cartilage destruction. These finding were recently validated in WHI, where women taking estrogens had significantly less joint replacement.

In conclusion, the pleiotropic effect of estrogens on several different tissues may match the complicated aetiology of OA in some important aspects.

About Dr Colin Holloway

Gp interested in natural hormone treatment for men and women of all ages

Posted on December 6, 2012, in Uncategorized. Bookmark the permalink. 1 Comment.

  1. Hello, I read your blogs regularly. Your story-telling style is awesome, keep it up!

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